The Zheng Laboratory
Faculty > Jing Zheng
Jing Zheng
Associate Professor, Obstetrics and Gynecology
jzheng@facstaff.wisc.edu
Aligned Research Focus
Basic stem cell science
Research Description
My long-term goal is to determine cellular and molecular mechanisms that control vasculogenesis and angiogenesis, ultimately regulating vascular growth and blood flow.
In my lab, one of our current research directions is to investigate mechanisms underlying endothelial differentiation from human embryonic stem cells and to establish stable endothelial cell lines from human embryonic stem cells. These stable cell lines will potentially provide a highly purified and homogenous endothelial cell supply not only for studying mechanisms that regulate angiogenesis but also for clinical applications.
Selected References
Qian XX, Mata-Greenwood E, Liao WX, Zhang H, Zheng J, Chen DB. Transcriptional regulation of endothelial nitric oxide synthase expression in uterine artery endothelial cells by c-Jun/AP-1. Mol Cell Endocrinol. 15;279(1-2):39-51. 2007.
Zheng J, Wen Y, Song Y, Wang K, Chen D, Magness RR. Activation of Multiple Signaling Pathways is Critical for Fibroblast Growth Factor 2- and Vascular Endothelial Growth Factor-Stimulated Ovine Fetoplacental Endothelial Cell Proliferation Biol Reprod. 2007 Sep 26; [Epub ahead of print]