The Vanderby Laboratory
Faculty > Ray Vanderby
Ray Vanderby
Professor, Orthopedics and Rehabilitation, Biomedical Engineering
vanderby@orthorehab.wisc.edu
Organ System/Disease Focus
Skeletal system tissue healing
Aligned Research Focus
Tissue regeneration of ligament, tendon, and cartilage
Research Description
I am particularly interested in orthopedic tissues (bone, ligament, tendon, cartilage, etc.). My research focuses on wound healing or regenerating these tissues via tissue engineering. This includes equal parts of functional characterization (e.g. biomechanics), microstructural morphology and composition, and the relevant biological sciences (cell and molecular biology, histology, etc.).
Additionally, I am interested in ultrasonic wave propagation in these tissues for clinically relevant characterization of tissue properties and functional loadings, as well as tissue regeneration for knee reconstruction procedures. To study these orthopedic issues, in my lab we use and adapt engineering and biological methods including experimental, analytical and computational approaches.
Selected References
Provenzano P, Alejandro-Osorio A, Valhmu W, Jensen K, Vanderby R. Intrinsic fibroblast mediated remodeling of damaged collagenous matrices in vivo. Matrix Biol. 23:543-555. 2005.
Provenzano P, Vanderby R. Collagen fibril morphology and organization: Evaluation in fetal and mature tendon and ligament. Matix Biol. 25(2):71-94. 2006.
Grorud K, Jensen K, Provenzano P, Vanderby R. Adjuvant Neuropeptides Can Improve Neuropathic Ligament Healing in a Rat Model. J Orthop Res. June; 25:703-712. 2007.
Provenzano PP, Alejandro-Osorio AL, Grorud KW, Martinez DA, Grindeland RE, Vailas AC, Vanderby R. Systemic administration of IGF-I enhances enhances healing of collagen extracellular matrices: evaluation of loaded and unloaded ligaments. BMC Physiol. 7:2. 2007.