The Shevde Laboratory
Faculty Nirupama (Rupa) Shevde
Nirupama (Rupa) Shevde
Senior Scientist, Director of Education and Outreach, WiCell Research Institute
rshevde@wicell.org
Research Description
Dr. Shevde is a Senior Scientist and the Director of the Education and Outreach at WiCell Research Institute. She also maintains an appointment as a Senior Scientist in the Department of Biochemistry at the University of Wisconsin-Madison. Dr. Shevde earned her Doctorate from Harvard and has conducted research for several years in the area of steroid hormones and their actions on the skeleton (Bone Biology). Prior to joining the WiCell team, she played a role as a consultant and was instrumental in developing some of the recent training courses offered to the scientific community. She and her team train scientists from all around the world to culture and maintain human embryonic stem cells through the training courses offered at WiCell. Dr. Shevde also leads a dynamic Outreach program that focuses on inspiring and empowering middle school and high school students who are our future scientists.
Her current research interests are centered on the regulation of cellular differentiation, particularly as it relates to human embryonic stem cells and their selective transition into cells of the osteoblast and osteoclast lineages.
Selected References
Shevde NK, Plum L, Claggett-Dame M, Yamamoto H, Pike JW. and DeLuca HF. (2002) A novel potent analog of vitamin D induces bone formation. PNAS 99(21): 13487-13491.
Yamamoto, H., Shevde, N.K., Warrier, A., Plum, L.A., DeLuca, H.F. and Pike, J.W. (2003) 2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 potently stimulates gene-specific DNA binding of the VitaminD receptor in osteoblasts. J. Biol. Chem. 278, 31756-31765.
Yamamoto H, Shevde NK, Warrier A, Plum LA, DeLuca HF, Pike JW. (2003) 2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 potently stimulates gene-specific DNA binding of the vitamin D receptor in osteoblasts. J Biol Chem. Aug 22;278(34):31756-65.
Fretz JA, Shevde NK, Singh S, Darnay BG, Pike JW. (2008) Receptor activator of nuclear factor-kappaB ligand-induced nuclear factor of activated T cells (C1) autoregulates its own expression in osteoclasts and mediates the up-regulation of tartrate-resistant acid phosphatase. Mol Endocrinol. Mar; 22(3):737-50.
Zella LA, Shevde NK, Hollis BW, Cooke NE, Pike JW. (2008) Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo. Endocrinology. Jul;149(7):3656-67.
Seda Tıglı R, Ghosh S, Laha MM, Shevde NK, Daheron L, Gimble J, Gümüşderelioglu M, Kaplan DL. (2009) Comparative chondrogenesis of human cell sources in 3D scaffolds. J Tissue Eng Regen Med. Apr 20. [Epub ahead of print]