The Bill Murphy Laboratory
Faculty > Bill L. Murphy
William L. Murphy
Assistant Professor, Biomedical Engineering, Pharmacology
wlmurphy@wisc.edu
William Murphy Laboratory Home Page
Organ System/Disease Focus
Orthopedic and cardiovascular
Aligned Research Focus
Tissue engineering, controlled stem cell culture
Research Description
In the Bioinspired Materials Laboratory, we are interested in developing "smart" biomaterials that mimic the complex signaling environments of natural tissue development. We place particular emphasis on temporal and spatial control over growth factor activity, gene transfer, and mechanical stimulation.
The materials developed in our lab are then used to understand and control stem cell differentiation, ultimately geared towards directed regeneration of a variety of human tissues. Our group is highly interdisciplinary, with research areas ranging from novel materials design approaches to basic stem cell biology.
Selected References
Murphy WL, Simmons CA, Kaigler D, Mooney DJ. Engineering bone regeneration via biomineral presentation and induced angiogenesis. J. Dent. Res. 83:204-210. 2004.
Murphy WL, Hsiong S, Richardson TP, Simmons CA, Mooney DJ. Effects of a bone-like mineral film on phenotype of adult human mesenchyman stem cells in vitro. Biomaterials. 26:303-310. 2005.
Murphy WL, Mercurius KO, Mrksich M. Active site-directed immobilization of a protein domain to mediate cell adhesion. Langmuir. 20:1026-1030. 2004.
Murphy WL, Dillmore WS, Modica J, Mrksich M. Dynamic Hydrogels: Translating a Protein Conformational Change into Macroscopic Motion. Angewandte Chemie Int. Ed. 46:3066-3069. 2007.
Sui Z, King WJ, Murphy WL. Dynamic materials based on a protein conformational change. Advanced Materials. In Press.