The Bill Murphy Laboratory
Faculty > Bill L. Murphy
William L. Murphy
Associate Professor, Biomedical Engineering, Orthopedics & Rehabilitation; Associate Director, Stem Cell & Regenerative Medicine Center
wlmurphy@wisc.edu
William Murphy Laboratory Home Page
Organ System/Disease Focus
Orthopedic and cardiovascular
Aligned Research Focus
Tissue engineering, controlled stem cell culture
Research Description
In the Bioinspired Materials Laboratory, we are interested in developing "smart" biomaterials that mimic the complex signaling environments of natural tissue development. We place particular emphasis on temporal and spatial control over growth factor activity, gene transfer, and mechanical stimulation.
The materials developed in our lab are then used to understand and control stem cell differentiation, ultimately geared towards directed regeneration of a variety of human tissues. Our group is highly interdisciplinary, with research areas ranging from novel materials design approaches to basic stem cell biology.
Selected References
J.S. Lee, J.S. Lee, A. Wagoner-Johnson,W.L. Murphy. Modular peptide growth factors for substrate-mediated stem cell differentiation, Angewandte Chemie Int. Ed., 2009; 48: 6266-6270.
Y. Lu, M.D. Markel, B. Nemke, J.S. Lee, B.K. Graf, W.L. Murphy. Influence of hydroxyapatite-coated and growth factor-releasing interference screws on tendon-bone healing in an ovine model, Arthroscopy, 2009; 20: 1427-34.
G.A. Hudalla, J.T. Koepsel, W.L. Murphy. Surfaces that sequester serum-borne heparin amplify growth factor activity. Advanced Materials, 2011; 23: 5415-5418.
G.A. Hudalla, N. Kouris, J.T. Koepsel, B.M. Ogle, W.L. Murphy. Harnessing endogenous growth factor activity modulates stem cell behavior. Integrative Biology, 2011; 3: 832–842.
J.S. Lee, D. Suarez-Gonzalez, W.L. Murphy. Calcium phosphate coatings for temporally controlled delivery of multiple proteins. Advanced Materials, 2011; 23: 4279–4284.