Karen Dyer Montgomery
Faculty Karen Dyer Montgomery
Karen Dyer Montgomery
Karen Dyer Montgomery
Laboratory Director, Cytogenetics Department (WiCell); Clinical Affiliate, Pathology (UW)
kdmontgomery@wisc.edu
Research Description
Chromosome breakage, cell survival, and gene expression related to heavy metals and pesticide exposure of lymphoblastoid and pluripotent cells in culture. This project assesses the activity of environmentally relevant levels of specific heavy metals (e.g. cobalt, arsenic), pesticides, and jet fuels (individually and in combination), in causing global changes in chromosome structure, and defines the mechanisms by which these changes occur.
Genetic instability in human embryonic stem cells and induced pluripotent stem cells. This project profiles cytogenetic changes in cultures of hES and iPS cells by classic chromosome analysis and by array comparative genomic hybridization (CGH).
Maintenance of X-inactivation in iPS cells. This project characterizes the activity of genes that reflect X-inactivation to determine if patterns are re-set by inducing pluripotency.
