The Markel Laboratory
Faculty > Mark D. Markel
Mark D. Markel
Vilas Distinguished Achievement Professor; Chair, Board of Trustees, ACVS Foundation; Chair, AO Research, and Review Commission, AO Foundation; Chair, Department of Medical Sciences;
Associate Dean for Advancement, School of Veterinary Medicine, University of Wisconsin
Organ System/Disease Focus
Musculoskeletal regeneration
Aligned Research Focus
Tissue engineering of bone and cartilage
Research Description
The Comparative Orthopaedic Research Laboratory which I co-direct is focused on the regeneration of both bone and cartilage. In bone, we have focused our efforts on the creation of bioengineered scaffolds which incorporate cytokines such as various bone morphogenetic proteins in order to enhance healing of critical sized bone defects. In cartilage, we have helped develop bioengineered constructs through the use of allogeneic, xenogeneic, and autogeneic chondrocytes and/or mesenchymal stem cells to create cartilage transplants for critical-sized cartilage defects.
Selected References
Kaplan LD, Lu Y, Snitzer JR, Nemke B, Hao ZL, Biro SM, Albiero WV, Markel MD, Baum SZ, Popkin C: The effect of early hyaluronic acid delivery on the development of acute articular cartilage lesions in a sheep model. Am J Sports Med 37:2323-2327, 2009.
Schaefer S, Lu Y, Seeherman H, Li JX, Markel MD: The effect of rhBMP-2 on tibial plateau fractures in a canine model. J Orthop Res 27:466-471, 2009.
Lu Y, Markel MD, Nemke B, Lee JS, Graf BK, Murphy WL: Influence of hydroxyapatite-coated and growth factor-releasing interference screws on tendon-bone healing in an ovine model. Arthroscopy 25:1427-1434, 2009.
Lee JS, Lu Y, Baer GS, Markel MD, Murphy WL: Controllable protein delivery from coated surgical sutures. J Mater Chem 20:8894-8903, 2010.
Lu Y, Lee JS, Nemke B, Baer G, Graf B, Murphy WL, Markel MD: Histologic evaluation of suture material loaded with basic fibroblast growth factor (bFGF) on acute rotator cuff repair in an ovine model. Curr Orthop Pract 22:425-431, 2011.