The Chang Laboratory
Faculty > Qiang Chang
Qiang Chang
Assistant Professor, Waisman Center
qchang@waisman.wisc.edu
Organ System/Disease Focus
Neurodevelopmental diseases, Rett Syndrome
Aligned Research Focus
Basic stem cell science
Research Description
We use various forms of gene targeting in mouse embryonic stem cells to generate genetically engineered mouse lines. One major focus of our lab is to use these mutant mice as animal models for human diseases, which allows us to study the molecular mechanism of diseases in vivo. In addition, we are beginning to explore the role of DNA methylation-dependent epigenetic regulatory mechanism in adult neurogenesis.
Selected References
Chang Q, Khare GD, Dani VS, Nelson SB, Jaenisch R. The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron 49(3):341-348. 2006.