The Brickson Laboratory
Faculty > Stacey Brickson
Stacey Brickson
Assistant Professor, Physical Therapy Program, Department of Orthopedics
brickson@ortho.wisc.edu
Aligned Research Focus
Tissue Engineering--muscle
Research Description
Dr. Brickson's research interest is stem-cell transplantation to treat acute skeletal muscle injury. Stem-cell transplantation has been investigated as a treatment for muscular dystrophy and cardiac infarction. Recently, muscle-derived stem cells (MDSC) were used to treat acute skeletal muscle injury. The synergistic effect of MDSCs and exercise has shown promise in minimizing fibrosis following contusion injury. Exercise is a cornerstone of rehabilitation in the treatment of muscle strain injuries and is therefore an inviting mechanical stimulus to enhance stem-cell regeneration potential. The limitation to existing investigations has been lack of a method to create a standardized injury in vivo, which is a prerequisite for gauging the effectiveness of treatment interventions. The majority of animal studies evaluating stretch injury have used repetitive cyclic contractions or employed invasive non-physiological models. Dr. Brickson's lab has recently designed an isokinetic device to create a reproducibly single stretch injury to the calf muscle in a mouse. Using this model, they have recently purposed a study to determine the effect of mouse mesenchymal stem cells on immune-cell regulated healing of skeletal muscle following stretch injury with and without treadmill exercise as a mechanical influence on MSCs.
Selected References
S. Brickson, L.L. Ji, K. Schell, R. Olabisi, B. St. Pierre Schneider, T.M. Best. M1/70 attenuates blood-borne neutrophil oxidants, activation, and myofiber damage following stretch injury. J. Appl Physiol 95: 969-976, 2003.
C. Chamberlain, E. Leiferman, K. Frisch, S. Wang, X. Yang, S. Brickson, R. Vanderby. The Influence of Interleukin-4 on Ligament Healing. Wound Healing and Regeneration 52(3):203-11, 2011.
C. Chamberlain, E. Leiferman, K. Frisch, S. Wang, X Yang, N. van Rooijen, S. Brickson, R. Vanderby. The Influence of Macrophage Depletion on Ligament Healing. Connective Tissue Research 19(3):426-35, 2011.