The Attie Laboratory
Faculty > Alan D. Attie
Alan D. Attie
Professor, Biochemistry
adattie@wisc.edu
Organ System/Disease Focus: Diabetes
Aligned Research Focus
β-cells, liver, adipose tissue, muscle
Research Description
In my laboratory, we aim to discover genes, networks, and pathways involved in diabetes. We use positional cloning from intercross and congenic mouse strains to identify causal disease genes. In addition, we carry out extensive microarray studies to identify genes involved in specific aspects of the disease; i.e., β-cell cell function and replication, and insulin signaling in target tissues. Our lab team also studies β-cell replication in response to particular hormones. This is a project with direct relevance to both type 1 and type 2 diabetes.
Selected References
Lan H, Chen M, Byers JE, Yandell BS, Stapelton DS, Mata CM, Mui ET, Flowers MT, Scheuler KL, Manly KF, Williams RW, Kendziorski CM, Attie AD. Combined expression trait correlations and expression quantative trait locus mapping. PLoS Genetics 2:52-61. 2006.
Clee SM, Yandell BS, Schueler KM, Rabaglia ME, Richards OC, Raines SM, Kabara EA, Klass DM, Stapleton DS, Gray-Keller MP, Boronenkov I, Raess PW, Flowers MT, Attie AD. Positional cloning of a type 2 diabetes quanitative trait locus. Nature Genetics 38:688-693. 2006.
Flowers JB, Oler AT, Nadler ST, Choi Y, Schueler KL, Yandell BS, Kendziorski CM, Attie AD. Abdominal obesity in BTBR male mice is associated with peripheral but not hepatic insulin resistance. Am. J. Physiol. 292:936-945. 2007.
Flowers JB, Rabaglia ME, Schueler KL, Flowers MT, Lan H, Keller MP, Ntambi JM, Attie AD. Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes 56:1228-1239. 2007.