The Attie Laboratory
Faculty > Alan D. Attie
Alan D. Attie
Professor, Biochemistry
adattie@wisc.edu
Organ System/Disease Focus: Diabetes
Aligned Research Focus
β-cells, liver, adipose tissue, muscle
Research Description
In my laboratory, we aim to discover genes, networks, and pathways involved in diabetes. We use positional cloning from intercross and congenic mouse strains to identify causal disease genes. In addition, we carry out extensive microarray studies to identify genes involved in specific aspects of the disease; i.e., β-cell cell function and replication, and insulin signaling in target tissues. Our lab team also studies β-cell replication in response to particular hormones. This is a project with direct relevance to both type 1 and type 2 diabetes.
Selected References
Lavine, J.A., Raess, P.W., Stapleton, D.S., Rabaglia, M.E., Suhonen, J.I., Schueler, K.L., Koltes, J.E., Dawson, J.A., Yandell, B.S., Samuelson, L.C., Beinfeld, M.C., Davis, D.B., Hellerstein, M.K., Keller, M.P., and Attie A.D. (2010) Cholecystokinin is Up-regulated in obese islets and expands b-cell mass by increasing b-cell survival.Endocrinol 151,3577-3588. PMID: 20534724
Davis, D.B., Lavine, J.A., Suhonen, J.I., Krautkramer, K.A., Rabaglia, M.E., Sperger, J.M., Fernandez, L.A., Yandell, B.S., Keller, M.P., Wang, I.M., Schadt, E.E., and Attie A.D. (2010) FoxM1 is up-regulated by obesity and stimulates b-cell proliferation. Mol. Endocrinol. 24,1822-1834 PMID: 20660304
Raines, S.M., Richards, O.C., Schneider, L.R., Schueler, K.L., Rabaglia, M.E., Oler, A.T., Stapleton, D.S., Genové, G., Dawson, C., and Attie A.D. (2011) Loss of PDGF-B activity increases hepatic vascular delivery of insulin and enhances insulin sensitivity. Am. J. Physiol. Endocrinol. Metab. 301, 517-526 PMID: 21673305.
Bhatnagar, S. Oler, A.T., Rabaglia, M.E., Stapleton, D.S., Schueler, K.L., Truchan, N.A., Worzella, S.L., Stoehr, J.P., Clee, S.M., Yandell, B.S., Keller, M.P., Thurmond, D.C., and Attie A.D. (2011) Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn‑2, a Negative Regulator of Insulin Secretion. PLoS Genetics 7(10), e1002323. PMID: 21998599
Keller MP, Attie A.D. Physiological insights gained from gene expression analysis in obesity and diabetes. Annu Rev Nutr. (2010) 30:341-64. PMID: 20415584